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. 2022 Apr 11;41:136. doi: 10.1186/s13046-022-02346-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — hY4F inhibits lung cancer progression through MAPK/NF-κB pathway. A The results of differentially expressed genes (DEG) cluster analysis presented by heatmap in A549 cells transfected with hY4F mimic/NC for 24 h. B KEGG pathway enrichment analysis of genes in response to hY4F overexpression. C Transcriptional sequencing results of five coding genes enriched into MAPK pathway. D QRT-PCR analysis results of the MAPK pathway related genes in Fig. 2A