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. Author manuscript; available in PMC: 2022 Apr 11.
Published in final edited form as: J Proteome Res. 2020 Sep 25;20(1):1–13. doi: 10.1021/acs.jproteome.0c00123

Table 2.

Mean Run Time, in Minutes, for Each Imputation Method by Data Set Size

BPCA EM IRMI kNN LLS MEAN MICE PCA RF
2 plexes (6 samples) 0.005 0.06 1.30 1.29 0.003 0.001 1.15 0.08 4.42
3 plexes (9 samples) 0.005 0.07 2.37 2.36 0.004 0.001 3.42 0.14 13.10
4 plexes (12 samples) 0.006 0.09 3.84 3.81 0.005 0.002 8.66 0.17 17.37
5 plexes (15 samples) 0.006 0.11 5.57 5.50 0.006 0.002 13.01 0.20 21.00
10 plexes (30 samples) 0.009 0.33 19.40 19.13 0.011 0.003 46.83 0.35 62.78
15 plexes (45 samples) 0.013 0.72 37.93 37.30 0.015 0.003 67.23 0.51 99.37
20 plexes (60 samples) 0.017 1.52 56.58 55.73 0.019 0.004 120.82 0.63 132.05
25 plexes (75 samples) 0.022 2.72 76.62 75.79 0.022 0.004 200.78 0.68 163.48