Fig. 3.

Multi-Species Model Performance. a Performance of multi-species brain model on MultiBr, MultiBrClade, MultiBrSpecies, and MultiBrVsLv (Supplemental Tables 20–21). b Performance of multi-species liver model on MultiLv, MultiLvClade, MultiLvSpecies, and MultiLvVsBr (Supplemental Tables 20–21). We reported area under the negative predictive value (NPV)-specificity (Spec.) curve instead of the AUPRC because these evaluation sets have more positives than negatives. c Divergence from mouse versus mean multi-species brain model predictions across mouse test chromosome brain OCR orthologs in Glires. d Divergence from mouse versus mean multi-species liver model predictions across mouse test chromosome liver OCR orthologs in Glires. e Performance of mouse-only liver model versus multi-species liver model on MultiLvLauras (Supplemental Tables 20–21). Animal silhouettes were obtained from PhyloPic [65]. AUC stands for area under the receiver operating characteristic curve, AUPRC stands for area under the precision-recall curve, and MYA stands for millions of years ago. The red curves are the best fit exponential function of the form y = ae^bx. The red dotted lines are the average prediction across test set negatives.