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. 2022 Apr 11;23:291. doi: 10.1186/s12864-022-08450-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Examples of Brain OCR Clusters with Predicted Lineage-Specific Open Chromatin Associated with Neuron Activity. We clustered the brain OCRs, where the features were the brain predictions in each Boreoeutheria species from Zoonomia, and then identified clusters whose regions had significant overlap with regions associated with mouse neuron firing and human neuron activity. Mouse neuron firing enhancers had significant overlap with a predicted Murinae-specific OCR cluster (cluster 43), and human neuron activity enhancers had significant overlap with a predicted Euarchonta and Carnivora-specific non-OCR cluster (cluster 74). Animal silhouettes were obtained from PhyloPic [65]