Table 3.
Reference intervals of creatinine and urea established by direct and two indirect sampling techniques
| Age Groups | Transferred PRINCE | GMM Partitioned LIS | SOM Partitioned LIS | |||
|---|---|---|---|---|---|---|
| LL (90% CI) | UL (90% CI) | LL (90% CI) | UL (90% CI) | LL (90% CI) | UL (90% CI) | |
| Creatinine (μmol/L) | ||||||
| 1 to < 6 years | 18.9 (17.9, 18.9) | 39.5 (39.5, 40.4) | 19.2 (19.1, 19.3) | 41.6 (41.5, 41.8) | 17.8 (17.6, 18.0) | 39.8 (39.4, 40.2) |
| 6 to < 12 years | 30.1 (30.1, 30.1) | 52.6 (51.6, 52.6) | 28.1 (27.9, 28.3) | 55.6 (55.4, 55.7) | 27.2 (27.0, 27.7) | 63.8 (62.6, 65.1) |
| 12 to < 17 years boys | 40.4 (39.5, 41.3) | 87.2 (85.3, 89.1) | 39.6 (38.9, 40.3) | 78.7 (78.1, 79.7) | 41.5 (40.8, 42.2) | 87.6 (85.5, 88.7) |
| 12 to < 17 years girls | 35.7 (34.8, 37.6) | 68.6 (67.6, 69.4) | 34.0 (33.4, 34.6) | 69.7 (69.1, 70.7) | 48.0 (47.8, 48.2) | 77.7 (76.7, 79.2) |
| Urea (mmol/L) | ||||||
| 1 to < 17 years | 2.62 (2.62, 2.62) | 6.50 (6.50, 6.60) | 2.53 (2.52, 2.55) | 6.06 (6.05, 6.07) | 2.54 (2.51, 2.56) | 6.37 (6.31, 6.42) |
PRINCE Pediatric Reference Intervals in China, LIS Laboratory Information System, GMM Gaussian Mixture Model, SOM Self-Organizing Map, LL lower limit, UL upper limit, CI confidence interval