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. Author manuscript; available in PMC: 2022 Apr 11.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2020 Oct 19;1868(1):118890. doi: 10.1016/j.bbamcr.2020.118890

Fig. 4.

Fig. 4.

Cellular Mn transport and trafficking. A model of a generic cell is depicted. Cells can take up Mn3+ from TF via TFR1-mediated endocytosis or Mn2+ via SLC39A14, SLC39A8, DMT1, or LTCCs, depending on the cell type. Mn is taken up into the mitochondrion via the MCU (mitochondrial uniporter complex) or possibly by mitoferrin 1/2. ATP13A2 (ATPase Cation Transporting 13A2) transports Mn into the lysosome. Mn is taken up into the Golgi apparatus via TMEM165 (Transmembrane Protein 165) or SPCA1 (secretory pathway Ca2 + -ATPase pump type 1). Cellular Mn export is mediated by SLC30A10 or possibly by FPN. Additional details are described in Section 4.2.