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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Mov Disord. 2021 Feb 6;36(9):2036–2047. doi: 10.1002/mds.28512

Fig. 2. Spatiotemporal distribution of α-Syn pathology in A53T BAC-SNCA Tg mice injected with α-Syn PFFs.

Fig. 2

(A) Schematic representation of experimental design. (B) Phosphorylated α-Syn immunohistochemistry (EP1536Y) in the indicated brain regions of the Tg-PFF mice at 2, 6, and 10MPI and the Tg-PBS mice at 10MPI. Arrows indicate pSyn-positive inclusions. Sept, septal nucleus; Str, Striatum; dCA1, dorsal CA1; HT, hypothalamus; MN, mammillary nucleus. Scale bar 50 μm. (C) Heat map colors represent the extent of α-Syn pathology (light yellow, mild pathology; yellow, moderate pathology; orange, severe pathology, red; very severe pathology).