Table 2.

Gut microbiota depletion studies on osteoarthritis.

Subject	Study design	Outcome	Citation
C57BL/6 mice	Compared conventionalized mice with and without antibiotic treatment	Antibiotic-induced intestinal microbiota depletion improvement of OA after joint injury	(25)
C57BL/6 mice	Compared conventionalized mice with and without antibiotic treatment	Antibiotic Treatment Prior to Injury Improves Post-Traumatic Osteoarthritis Outcomes in Mice	(85)
C57BL/6 mice	Compared GF and conventionalized mice	Gree free status was protective against early OA changes in bone structure.	(86)
C57BL/6 mice	Compared GF and conventionalized mice	Only the microbiota transplantation from the knee OA with metabolic syndrome and MLI resulted in an increase in the severity of OA	(84)