Table 2.

HC and TN means on acylcarnitine factor 1 and concentrations (N = 45)

Variable name	Concentration, μM, meana		P-value	Variable name	Concentration, μM, meana		P-value
	HCs	JDM (TN)			HCs	JDM (TN)
Factor 1	−0.470	0.423	0.049*	C12:1	−0.312	0.281	0.206
C2b	−0.361	0.325	0.140	C12-OH/C10-DC	−0.319	0.287	0.196
C3	−0.340	0.306	0.166	C14	−0.406	0.365	0.094
C4/Ci4	−0.170	0.153	0.480	C14:1	−0.390	0.351	0.108
C4-OH	−0.500	0.450	0.040*	C14:2	−0.212	0.191	0.395
C4-DC/Ci4-DC	−0.372	0.335	0.120	C14:1-OH	−0.146	0.131	0.562
C5	−0.073	0.066	0.760	C14-OH/C12-DC	−0.155	0.140	0.536
C5:1	0.187	−0.168	0.456	C16	−0.440	0.396	0.060
C5-DC	0.078	−0.070	0.758	C16-OH/C14-DC	−0.513	0.462	0.030*
C5-OH/C3-DC	−0.514	0.463	0.029*	C16:1	−0.484	0.436	0.041*
C6	−0.571	0.514	0.013*	C16:1-OH/C14:1-DC	−0.430	0.387	0.074
C7-DC	−0.086	0.077	0.734	C16:2	−0.255	0.229	0.306
C8	−0.210	0.189	0.400	C18	−0.672	0.605	0.002**
C8:1	0.332	−0.299	0.177	C18-OH/C16-DC	−0.524	0.472	0.030*
C8:1-DC	0.053	−0.048	0.833	C18:1	−0.640	0.576	0.004**
C8-OH/C6-DC	−0.038	0.034	0.880	C18:1-DC	−0.546	0.491	0.020*
C8:1-OH/C6:1-DC	0.547	−0.492	0.019*	C18:1-OH/C16:1-DC	−0.533	0.480	0.020*
C10	−0.154	0.139	0.540	C18:2	−0.283	0.255	0.240
C10:1	−0.019	0.017	0.942	C18:2-OH	−0.196	0.177	0.433
C10:2	0.226	−0.204	0.364	C20	−0.363	0.326	0.130
C10:3	0.377	−0.339	0.122	C20-OH/C18-DC	−0.513	0.461	0.029*
C10-OH/C8-DC	−0.096	0.086	0.703	C20:4	0.077	−0.069	0.760
C12	−0.250	0.225	0.315	C22	−0.181	0.163	0.690

Twenty-six of 45 acylcarnitine concentrations (in bold text) loaded >0.6 on a PCA-derived factor (PC factor 1) composed primarily of LCACs. PC factor 1 scores were significantly greater in the TN patients compared with the HCs (P = 0.049). Twelve individual mostly LCAC concentrations were significantly higher in the TN group.

^aMean concentrations are based on data logged to the base 10 then standardized.

^bAcylcarnitines loading ≥0.60 are in bold.

^* P < 0.05,

^** P < 0.01.