Table 2.

Comparison of plasma biomarkers between low-to-moderate physical activity (LMPA) and high physical activity (HPA) groups.

	LMPA	HPA	p(F)	pa(Fa)
A β1−42
(a) All	0.344 ± 0.087	0.312 ± 0.060	0.017 (5.844)	0.024 (5.189)
(b) ε4–	0.364 ± 0.090	0.316 ± 0.058	0.003 (9.002)	0.004 (8.602)
ε4+	0.311 ± 0.073	0.305 ± 0.064	0.772 (0.085)	0.986 (0.000)
(c) Aβ-	0.367 ± 0.091	0.324 ± 0.056	0.014 (6.283)	0.012 (6.576)
Aβ+	0.315 ± 0.074	0.295 ± 0.061	0.267 (1.257)	0.422 (0.655)
A β1−40
(a) All	8.731 ± 2.165	8.054 ± 1.686	0.043 (4.184)	0.057 (3.698)
(b) ε4–	8.948 ± 2.362	7.944 ± 1.537	0.020 (5.655)	0.019 (5.745)
ε4+	8.362 ± 1.766	8.251 ± 1.937	0.770 (0.086)	0.760 (0.094)
(c) Aβ-	8.849 ± 2.375	7.902 ± 1.631	0.043 (4.220)	0.031 (4.817)
Aβ+	8.586 ± 1.904	8.262 ± 1.761	0.483 (0.499)	0.867 (0.043)
APP 669−711
(a) All	0.296 ± 0.061	0.270 ± 0.054	0.006 (7.669)	0.007 (7.520)
(b) ε4–	0.305 ± 0.064	0.259 ± 0.049	<0.001 (15.512)	<0.001 (14.810)
ε4+	0.282 ± 0.054	0.289 ± 0.060	0.628 (0.237)	0.543 (0.375)
(c) Aβ-	0.294 ± 0.064	0.261 ± 0.050	0.012 (6.612)	0.012 (6.580)
Aβ+	0.299 ± 0.059	0.282 ± 0.059	0.227 (1.487)	0.260 (1.294)

Plasma Aβ₁₋₄₂, Aβ₁₋₄₀, and APP_669−711 levels were compared between low-to-moderate physical activity (LMPA) and high physical activity (HPA) groups in all (a) participants, (b) participants stratified by apolipoprotein E (APOE) ε4 genotype status (ε4–/ε4+), and (c) brain amyloid status (Aβ-/Aβ+), using general linear models. Physical activity was measured by the International Physical Activity Questionnaire (IPAQ), and brain amyloid deposition was measured using positron emission tomography. Plasma Aβ₁₋₄₂, Aβ₁₋₄₀, and APP_669−711 data were natural log transformed to better approximate normality and variance homogeneity. p^a(F^a) represents p-values adjusted for age and sex. P < 0.05 (italic) was considered significant. Data are presented in mean ± SD.