Table 3.

Comparison of plasma biomarkers ratios between low-to-moderate physical activity (LMPA) and high physical activity (HPA) groups.

	LMPA	HPA	p(F)	pa(Fa)
APP 669−711 / A β1−42
(a) All	0.880 ± 0.148	0.874 ± 0.140	0.801 (0.064)	0.653 (0.203)
(b) ε4–	0.855 ± 0.140	0.826 ± 0.124	0.303 (1.073)	0.311 (1.039)
ε4+	0.924 ± 0.154	0.960 ± 0.127	0.355 (0.870)	0.556 (0.351)
(c) Aβ-	0.814 ± 0.130	0.809 ± 0.108	0.848 (0.037)	0.840 (0.041)
Aβ+	0.963 ± 0.128	0.963 ± 0.130	0.984 (0.000)	0.694 (0.157)
Aβ1−40/Aβ1−42
(a) All	25.76 ± 4.16	25.97 ± 3.47	0.736 (0.114)	0.709 (0.140)
(b) ε4–	24.89 ± 4.07	25.28 ± 3.25	0.611 (0.261)	0.645 (0.124)
ε4+	27.24 ± 3.97	27.21 ± 3.58	0.977 (0.001)	0.659 (0.197)
(c) Aβ-	24.31 ± 3.90	24.43 ± 3.12	0.881 (0.022)	0.963 (0.002)
Aβ+	27.55 ± 3.81	28.08 ± 2.77	0.533 (0.394)	0.303 (1.079)
Composite z-score
(a) All	−0.004 ± 0.882	0.003 ± 0.816	0.960 (0.003)	0.966 (0.002)
(b) ε4–	−0.208 ± 0.844	−0.256 ± 0.741	0.771 (0.085)	0.751 (0.101)
ε4+	0.344 ± 0.852	0.466 ± 0.744	0.582 (0.307)	0.534 (0.392)
(c) Aβ-	−0.427 ± 0.695	−0.429 ± 0.625	0.988 (<0.001)	0.927 (0.009)
Aβ+	0.522 ± 0.810	0.593 ± 0.665	0.703 (0.147)	0.720 (0.130)

APP_669−711/Aβ₁₋₄₂, and Aβ₁₋₄₀/Aβ₁₋₄₂ ratios and the composite z-score of the same ratios were compared between low-to-moderate physical activity (LMPA) and high physical activity (HPA) groups in all (a) participants, (b) participants stratified by apolipoprotein E (APOE) ε4 genotype status (ε4–/ε4+), and (c) brain amyloid status (Aβ-/Aβ+), using general linear models. Physical activity was measured by the International Physical Activity Questionnaire (IPAQ), and brain amyloid deposition was measured using positron emission tomography. p^a(F^a) represents p-values adjusted for age and sex. P < 0.05 (italic) was considered significant. Data are presented in mean ± SD.