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. 2022 Mar 23;14(7):1638. doi: 10.3390/cancers14071638

Figure 2.

Figure 2

Lollipop plots of pathogenic/likely pathogenic variants mapped on BRCA1 (A) and BRCA2 (B) protein domains. BRCA1 domains: green, C3HC4 type RING finger; red, serine-rich domain associated with BRCT; blue, ethylene insensitive 3; yellow, BRCA1 C terminus domain. BRCA2 domains: green, BRCA2 repeats; red, BRCA2 helical; blue, BRCA2 oligonucleotide /oligosaccharide-binding domain 1; yellow, tower; purple, BRCA2 oligonucleotide/oligosaccharide-binding, domain 3. Each variant is represented by a single lollipop; the stick lengths indicate variant frequency (y-axis) and dots are color-coded according to variant type: green, missense mutations; black, truncating mutations (frameshift or nonsense mutations); brown dots, in-frame mutations. Intronic variants are not represented. Graphs created using Mutation Mapper tool, cBioportal (http://www.cbioportal.org/mutation_mapper) (accessed on 25 January 2022) and manually curated. BRCA1: RefSeq: NM_007294, Ensembl: ENST00000357654, CCDS: CCDS11453, UniProt: BRCA1_HUMAN. BRCA2:RefSeq: NM_000059, Ensembl: ENST00000380152, CCDS: CCDS9344, UniProt: BRCA2_HUMAN. * Exons number according traditional numbering, skipping exon 4 (1,2,3,5–24). Cluster regions: yellow BCCR: Breast cancer cluster region; orange OCCR: ovarian cancer cluster region.