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The new workflow for the management of women affected by ovarian cancer. Blue boxes: The workflow for the management of women affected by OC proposed in 2019 [20]. Red boxes: new steps introduced starting from January 2020. OC: ovarian cancer; P/LP: pathogenic/likely pathogenic variants; VUS: variant of uncertain significance; HBOC: hereditary breast and ovarian cancer syndrome; MLPA: Multiple-Ligation Probe-Amplification; LR: Large Rearrangements.
