Figure 4.

Distribution of tumor microenvironment types based on PD-L1 status and the number of intratumoral CD8+ lymphocytes across EBV+, MMRd, and EBV-MMRpGCs. An area proportional tree map illustrates the frequency of the different tumor microenvironment types depending on the EBV and MMR status of the tumors. Tumor microenvironment types are based on the PD-L1 and CD8^int status: type I (adaptive immune resistance; PD-L1+/CD8^int high), type II (immunological ignorance; PD-L1-/CD8^int low), type III (intrinsic induction; PD-L1+/CD8^int low), and type IV (tolerance; PD-L1-/CD8^int high).