Table 4.
Best mean classification accuracies achieved for prediction of pCR based on each MRI imaging sequence as well as in combination with PET for prediction of pCR in TN/HER2+.
| Images | AUC | Sensitivity | Specificity | PPV | NPV | Accuracy |
|---|---|---|---|---|---|---|
| ADC | 0.64 (0.43–0.85) |
82.4 (56.6–96.2) |
60.0 (32.3–83.7) |
70.0 (54.7–81.8) |
75.0 (49.8–90.1) |
71.9 (53.5–86.3) |
| T2 | 0.75 (0.57–0.93) |
76.5 (50.1–93.2) |
66.7 (38.4–88.2) |
72.2 (54.8–84.8) |
71.4 (49.7–86.4) |
71.9 (53.3–86.3) |
| Dynamic 1 | 0.75 (0.57–0.93 |
82.4 (56.6–96.2) |
46.7 (21.3–73.4) |
63.6 (50.9–74.7) |
70.0 (42.2–88.2) |
65.6 (46.8–81.4) |
| Dynamic 2 | 0.74 (0.55–0.93) |
82.4 (56.6–96.2) |
73.3 (44.9–92.2) |
77.8 (59.5–89.3) |
78.6 (55.7–91.5) |
78.1 (60.0–90.7) |
| Dynamic 3 | 0.82 (0.65–0.98) |
88.2 (63.6–98.5) |
80.0 (51.9–95.7) |
83.3 (64.2–93.3) |
85.7 (61.4–95.8) |
84.4 (67.2–94.7) |
| Dynamic 4 | 0.83 (0.68–0.98) |
82.4 (56.6–92.4) |
73.3 (44.9–92.2) |
77.8 (59.5–89.3) |
78.6 (55.7–91.5) |
78.1 (60.0–90.7) |
| Dynamic 5 | 0.59 (0.38–0.80) |
64.7 (33.3–85.8) |
66.7 (38.4–88.2) |
68.8 (49.8–83.0) |
62.5 (44.4–77.7) |
65.6 (46.8–81.4) |
| All Dynamics | 0.92 (0.82–1.00) |
88.2 (63.6–98.5) |
86.7 (59.5–98.3) |
88.2 (67.1–96.5) |
86.7 (63.5–96.0) |
87.5 (71.0–96.5) |
| All MR | 0.92 (0.82–1.00) |
88.2 (63.6–98.5) |
86.7 (59.5–98.3) |
88.2 (67.1–96.5) |
86.7 (63.5–96.0) |
87.5 (71.0–96.5) |
| PET | 0.67 (0.48–0.86) |
70.6 (44.0–89.7) |
60.0 (32.3–83.7) |
66.7 (50.0–80.0) |
64.3 (43.6–80.7) |
65.6 (46.8–81.4) |
| All MR and PET | 0.92 (0.82–1.00) |
88.2 (63.6–98.5) |
86.7 (59.5–98.3) |
88.2 (67.1–96.5) |
86.7 (63.5–96.0) |
87.5 (71.0–96.5) |