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. 2022 Mar 23;14(7):1625. doi: 10.3390/cancers14071625

Figure 9.

Figure 9

miR-199a-5p inhibition and/or let-7a-5p activation impairs DU145 and PC3 cell motility. (A,B) Representative images from the scratch assay (0 and 48 h) for DU145 and PC3 cells show the regulatory role of miR-199a-5p and let-7a-5p on cell migration (n = 3) (C,D). 25 nM of miR-199a-5p inhibitor and/or 10nM of let-7a-5p mimic significantly inhibited the motility of both DU145 and PC3 cells (n = 3)]. * p < 0.001. Data are presented as the mean ± SD. Matched miRNAs were further analyzed for their potential targets using DIANA-mirPath v 3.0 and dbEMT databases (Figure 3A–D) for their potential regulating of EMT gene expression as presented in volcano plots (Figure 3A,B), and compared to the NanoString® mRNA analysis (Figure 4 and Figure 5).