TABLE 1.

Characteristics of 174 patients evaluated in the population pharmacokinetic analysis of nelfinavir

Characteristic	No. of patients	% Total study population
Sex (men/women)	155/19	89/11
Mean age (range)	37 (21–63)b
Mean total body weight (range)	77.7 (42–140)c
Baseline CD4 count (cells per μl)
<100	35	20
<300 and >100	59	34
<300	80	46
Baseline viral RNA (copies/ml)
>100,000	68	39
>50,000 and <100,000	43	25
>50,000	63	36
Race
Caucasian	136	78
Black	21	12
Asian	3	2
Hispanic	7	4
Latin American	4	2
Native American	3	2
Concomitant medications
Azole (fluconazole)	25 (23)	15 (13)
Macrolide	18	10
Quinolone	12	8
Rifabutin	5	3
History of liver disease	60	34
LFTs grade 2 or higher	51	29
Plasma M8-to-nelfinavir ratioa
Low ratio (<0.1)	6	3
Intermediate ratio (>0.1 and <0.3)	67	38
High ratio (>0.3)	37	21

^aM8 concentrations were available for only 110 of 174 patients in this study. 

^bIn years. 

^cIn kilograms.