Table 4.
Adverse events.
| LENV Group (n = 146) | ATE/BEV Group (n = 86) | |||
|---|---|---|---|---|
| Adverse Events | Any Grade n (%) |
Grade 3 or 4 n (%) |
Any Grade n (%) |
Grade 3 or 4 n (%) |
| Hypertension | 22 (15.1) | 4 (2.7) | 36 (41.9) | 5 (5.8) |
| AST elevation | 35 (24.0) | 1 (0.7) | 32 (37.2) | 7 (8.1) |
| Thrombocytopenia | 22 (15.1) | 0 | 31 (36.0) | 3 (3.5) |
| Fatigue | 36 (24.7) | 3 (2.1) | 31 (36.0) | 0 |
| Anemia | 8 (5.5) | 1 (0.7) | 22 (25.6) | 1 (1.2) |
| Anorexia | 42 (28.8) | 10 (6.8) | 20 (23.3) | 0 |
| ALT elevation | 29 (19.9) | 0 | 19 (22.1) | 2 (2.3) |
| Proteinuria | 25 (17.1) | 4 (2.7) | 19 (22.1) | 1 (1.2) |
| Total bilirubin elevation | 22 (15.1) | 1 (0.7) | 15 (17.4) | 4 (4.7) |
| Nausea | 14 (9.6) | 0 | 11 (12.8) | 0 |
| Rash | 2 (1.4) | 0 | 10 (11.6) | 2 (2.3) |
| Neutropenia | 12 (8.2) | 0 | 10 (11.6) | 2 (2.3) |
| Pruritus | 4 (2.8) | 0 | 7 (8.1) | 1 (1.2) |
| Gastrointestinal bleeding | 4 (2.7) | 4 (2.7) | 5 (5.8) | 3 (3.5) |
| Vomiting | 6 (4.1) | 0 | 4 (4.7) | 0 |
| Gastrointestinal perforation | 1 (0.7) | 1 (0.7) | 3 (3.5) | 3 (3.5) |
| Diarrhea | 20 (13.7) | 4 (2.7) | 3 (3.5) | 0 |
| Hypothyroidism | 12 (8.2) | 0 | 2 (2.3) | 0 |
| Intracranial hemorrhage | 0 | 0 | 1 (1.2) | 1 (1.2) |
| Pulmonary embolism | 1 (0.7) | 1 (0.7) | 1 (1.2) | 1 (1.2) |
AST, aspartate aminotransferase; ALT, alanine aminotransferase.