Table 1.

The two columns to the right show the mean immunoreactivity scores (IRS) on IHC in cruciate ligaments and synovial membranes, respectively; in each column, the first vertical row of numbers represents relaxin-specific IRS, the second row LGR7-, and the third LGR8-specific IRS for each dog. Abbreviations: MP modified Maquet procedure; TTA tibial tuberosity advancement; TPLO tibial plateau levelling osteotomy; DE ANGELIS extracapsular suture stabilization; M male; F female; FS female sterilized, NA not available. (a) Seven control dogs without CCL damage (CCLc). (b) Eighteen dogs with CCLD (CCLr).

(a)
No. Case Control Group CCLc	Age (Years)	Breed	Body Weight (kg)	Sex	IRS IHC Ligaments REL; LGR7; LGR8 n = 7		IRS IHC Synovial Membranes, REL n = 5; LGR7 n = 4; LGR8 n = 5
1	5	MIXED BREED	23	FS	1; 1; 1		NA
2	10	MIXED BREED	7	M	2; 2; 2		3; 4; 6
3	8	ROTTWEILER	36	M	2; 1; 4		1; 2; 2
4	9	MIXED BREED	31	FS	4; 4; 4		4; NA; 2
5	6	MIXED BREED	8	FS	1; 1; 2		4; 4; 4
6	10	MIXED BREED	11	FS	2; 4; 2		NA
7	4	ENGLISH BOULEDOGUE	20	M	3; 4; 3		2; 4; 4
	Median 8 Range 4–10		Median 20 Range 7–36		$\overline{\mathrm{x}}$ 2.62 SE 0.59 $\overline{\mathrm{x}}$ 2.42 SE 0.57 $\overline{\mathrm{x}}$ 2.57 SE 0.42		$\overline{\mathrm{x}}$ 2.8 SE 0.58 $\overline{\mathrm{x}}$ 3.5 SE 0.5 $\overline{\mathrm{x}}$ 3.6 SE 0.74
(b)
No. Case Sample Group CCLr	Age (Years)	Breed	Body Weight (kg)	Sex	Surgical Procedure	Time Since Injury (Days)	$\overline{\mathbf{x}}$ IRS IHC Ligaments REL; LGR7; LGR8 n = 18	$\overline{\mathbf{x}}$ IRS IHC Synovial Membranes, REL; LGR7;LGR8 n = 14
1	8	MIXED BREED	25	FS	TPLO	UNKNOWN	4; 4; 4	6; 9; 6
2	4	LABRADOR RETRIVER	34	FS	MP TTA + partial meniscectomy	14	9; 9; 6	9; 9; 6
3	7	JACK RUSSEL TERRIER	6	M	DE ANGELIS	70	6; 8; 6	9; 4; 4
4	5	MIXED BREED	15	F	DE ANGELIS	21	9; 9; 9	9; 9; 9
5	5	CAIRN TERRIER	11	FS	DE ANGELIS	60	4; 6; 4	NA
6	11	YORKSHIRE	5	M	DE ANGELIS	60	4; 4; 6	NA
7	7	MIXED BREED	9	M	DE ANGELIS	30	4; 4; 4	4; 4; 6
8	5	MIXED BREED	18	FS	MP TTA+ partial meniscectomy	60	6; 9; 9	2; 6; 6
9	2	CORSO	44	F	MP TTA	30	4; 9; 9	4; 9; 9
10	15	JACK RUSSEL	6	FS	De ANGELIS	UNKNOWN	6; 6; 6	NA
11	7	BOXER	33	FS	DE ANGELIS	30	9; 9; 9	6; 9; 9
12	8	MIXED BREED	27	F	DE ANGELIS	15	4; 4; 4	6; 6; 6
13	8	MIXED BREED	41	F	MP TTA	30	4; 4; 4	9; 9; 9
14	7	BARBONE MEDIO	14	M	DE ANGELIS	10	4; 6; 6	9; 9; 6
15	2	CORSO	42	F	MP TTA	60	4; 9; 4	NA
16	5	AMERICAN STAFFORDSHIRE TERRIER	17	FS	MP TTA	30	6; 9; 6	6; 4; 6
17	5	AMERICAN STAFFORDSHIRE TERRIER	16	FS	MP TTA	30	9; 6; 9	4; 9; 6
18	5	AMERICAN STAFFORDSHIRE TERRIER	18	M	MP TTA	21	6; 9; 9	9; 9; 6
	Median 6 Range 2–15		Median 17.5 Range 5–44			Median 30 Range 10–70	$\overline{\mathrm{x}}$ 5.55 SE 0.48 $\overline{\mathrm{x}}$ 6.88 SE 0.51 $\overline{\mathrm{x}}$ 6.33 SE 0.49	$\overline{\mathrm{x}}$ 6.57 SE 0.65 $\overline{\mathrm{x}}$ 7.5 SE 0.58 $\overline{\mathrm{x}}$ 6.7 SE 0.42