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. 2022 Mar 22;14(7):1609. doi: 10.3390/cancers14071609

Figure 4.

Figure 4

Mouse-derived organoids containing Cdh1−/− cells are more sensitive to the growth inhibiting effects of dasatinib. Representative photos of WT and Cdh1−/− gastric (A) and mammary (B) organoids after 48 h treatment with DMSO or dasatinib. Bar graphs showing relative area of DMSO or dasatinib treated gastric (C) or mammary (D) organoids. Bar graphs showing relative area of DMSO or dasatinib treated WT or Tp53−/−Cdh1−/− gastric (E) and mammary (F) organoids. (For all graphs, error bars = SEM; * p < 0.05, ** p < 0.01 and *** p <0.001; n ≥ 3 independent biological replicates; unpaired two-sided t-test).