Table 1.
Top 20 AKT3-associated genes after significance and fold-change filtering (FDR adjusted p-value < 0.05 and at least 2-fold up- or down-regulation) in the TCGA and GEO datasets. Expression fold change (FC) and FDR-adjusted p-value are shown per gene, for each data set. Genes are sorted based on the average rank of the adjusted p-value across the two data sets. The full list of 51 AKT3-specific genes is provided in Table S3.
| Gene | TCGA FC | GEO FC | TCGA Adj p-Value | GEO Adj p-Value |
|---|---|---|---|---|
| DDR2 | 5.13 | 2.04 | 6.84 × 10−51 | 2.89 × 10−35 |
| CDH11 | 3.14 | 2.33 | 1.99 × 10−43 | 1.26 × 10−31 |
| AOC3 | 4.65 | 2.45 | 2.91 × 10−43 | 1.57 × 10−30 |
| MSRB3 | 4.12 | 2.06 | 9.74 × 10−43 | 6.82 × 10−30 |
| FSTL1 | 2.61 | 2.07 | 9.96 × 10−43 | 4.76 × 10−29 |
| DPYSL3 | 4.28 | 2.07 | 4.95 × 10−42 | 1.46 × 10−28 |
| COL8A1 | 5.33 | 2.02 | 8.41 × 10−42 | 9.60 × 10−28 |
| TIMP3 | 3.16 | 2.16 | 9.55 × 10−40 | 1.96 × 10−27 |
| CCDC80 | 5.29 | 2.28 | 9.89 × 10−39 | 5.48 × 10−27 |
| LTBP1 | 3.00 | 2.10 | 1.54 × 10−38 | 4.74 × 10−26 |
| PDLIM3 | 4.40 | 2.50 | 2.10 × 10−38 | 1.85 × 10−25 |
| C1S | 2.87 | 2.37 | 3.61 × 10−36 | 2.66 × 10−25 |
| GREM1 | 6.27 | 2.35 | 9.83 × 10−36 | 3.64 × 10−25 |
| GLT8D2 | 2.78 | 2.18 | 2.28 × 10−35 | 1.88 × 10−24 |
| GAS1 | 5.25 | 3.11 | 2.37 × 10−35 | 2.77 × 10−24 |
| TNS1 | 3.67 | 2.35 | 5.32 × 10−35 | 5.75 × 10−24 |
| KCNMA1 | 7.31 | 3.77 | 3.20 × 10−34 | 1.16 × 10−23 |
| MYLK | 4.59 | 2.61 | 3.98 × 10−34 | 1.31 × 10−23 |
| C1R | 2.76 | 2.14 | 6.15 × 10−34 | 2.33 × 10−23 |
| ADAMTS1 | 2.75 | 2.08 | 1.82 × 10−33 | 3.75 × 10−23 |