Table 2.
Reactome pathways significantly enriched (Benjamini–Hochberg-adjusted p-value < 0.05) within a list of 35 AKT3-associated genes. Shown from left to right are Reactome pathway name, Benjamini–Hochberg-adjusted p-value, symbols for genes differentially expressed in the dataset by pathway, the number of genes differentially expressed in the dataset by pathway and the total number of genes within the Reactome database for each pathway.
| Reactome Pathway | Adj p-Value | Differentially Expressed Genes in Pathway | No. of Differentially Expressed Genes in Pathway | Total No. of Genes in Pathway |
|---|---|---|---|---|
| Extracellular matrix organization | 1.40 × 10−6 | COL6A3, COL8A1, COL15A1, FBLN1, FN1, TNC, LTBP1, MMP2, DDR2, ASPN, SDC2, ADAMTS1 | 12 | 289 |
| Regulation of IGF transport and uptake by IGFBPs | 1.00 × 10−4 | FSTL1, FN1, TNC, IGFBP5, LTBP1, MMP2, SDC2 | 7 | 120 |
| Smooth Muscle Contraction | 1.00 × 10−4 | MYH11, MYLK, ACTA2, ACTG2, CALD1 | 5 | 38 |
| Post-translational protein phosphorylation | 0.00058 | FSTL1, FN1, TNC, IGFBP5, LTBP1, SDC2 | 6 | 103 |
| Muscle contraction | 0.0022 | MYH11, MYLK, PLN, ACTA2, ACTG2, VIM, CALD1 | 7 | 194 |
| Degradation of the extracellular matrix | 0.0045 | COL6A3, COL8A1, COL15A1, FN1, MMP2, ADAMTS1 | 6 | 133 |
| Collagen degradation | 0.025 | COL6A3, COL8A1, COL15A1, MMP2 | 4 | 59 |
| Non-integrin membrane-ECM interactions | 0.045 | FN1, TNC, DDR2, SDC2 | 4 | 59 |