Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 25;14(7):1662. doi: 10.3390/cancers14071662

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Identified potential transcription factors (TFs) for regulation of 23 DEGs. TFs prediction was performed using the online tools Chea3, Encode, Opposum, Transfac/Jasper and Trust. (A) List of TFs predicted by at least three different programs. (B) Representative YY1 staining of FVB/N wild-type skin (scale bar: 50 μm) and a skin tumour of a K14-HPV8-CER mouse (scale bar: 100 μm) taken 24 days post UV treatment. (C) Venn plot of miRNAs predicted to target ≥ 2 TFs and miRNAs previously shown to be deregulated in skin tumours of K14-HPV8-CER mice [15]. Analysis led to the identification of three miRNAs, namely mmu-miR-155-5p, mmu-miR-181b-5p and mmu-miR-218-5p to be upstream regulators. (D) The TFs as targets of these miRNAs are listed.