Table 4.

HRs for CCA and HCC incidence according to liver disorder status.

	CCA Incidence									HCC Incidence
Variable/Group	Normal Liver Group				Liver Disorder Group				Pinteraction §	Normal Liver Group				Liver Disorder Group				Pinteraction §
	No. of Cases	p	HR	95% CI	No. of Cases	p	HR	95% CI		No. of Cases	p	HR	95% CI	No. of Cases	p	HR	95% CI
Alcohol use, g ethanol/day
None	144		1.00	Reference	599		1.00	Reference		357		1.00	Reference	1030		1.00	Reference
<10	55	0.208	0.89	0.74–1.07	167	0.873	0.97	0.70–1.35	0.638	163	0.823	0.98	0.80–1.19	379	<0.001	0.80	0.70–0.90	0.082
10–39	80	0.077	1.18	0.98–1.42	197	0.513	1.11	0.81–1.51	0.733	150	0.361	0.91	0.73–1.12	482	0.001	0.81	0.72–0.91	0.357
≥40	56	0.063	1.30	0.99–1.71	64	0.005	1.64	1.16–2.31	0.304	54	0.144	1.25	0.93–1.69	230	0.291	0.92	0.79–1.07	0.075
140 g ethanol/week	343	0.027	1.08	1.01–1.16	1045	0.012	1.11	1.02–1.20	0.682	747	0.079	1.07	0.99–1.16	2173	0.875	1.00	0.96–1.04	0.101
Alcohol use, frequency
None	144		1.00	Reference	599		1.00	Reference		357		1.00	Reference	1030		1.00	Reference
2/month–2/week	93	0.759	0.98	0.83–1.14	269	0.959	0.99	0.74–1.32	0.916	253	0.649	0.96	0.80–1.15	653	<0.001	0.79	0.71–0.88	0.073
3–4 times/week	99	0.757	1.04	0.81–1.34	168	0.368	1.19	0.82–1.73	0.565	122	0.583	0.92	0.70–1.23	450	0.053	0.86	0.74–1.00	0.655
Almost daily	7	0.003	1.42	1.12–1.80	9	0.018	1.50	1.07–2.11	0.789	15	0.101	1.27	0.95–1.69	40	0.247	0.91	0.78–1.07	0.046

Abbreviations: HR—hazard ratio; 95% CI—95% confidence interval. P_interaction ^§—p value for interaction test between liver disorder status groups.