Table 2.

Discriminative ability of single markers and models.

Marker or Model	C-Index (95% CI)	Classification Cutoff	Accuracy	Sensitivity	Specificity	PPV	NPV
Age (years)	0.76 (0.64–0.88)	51.46	0.78	0.85	0.67	0.80	0.74
CA125 (U/mL)	0.87 (0.79–0.95)	32.39	0.83	0.79	0.90	0.92	0.73
OPN (pg/mL)	0.81 (0.72–0.91)	24,850.70	0.82	0.89	0.70	0.82	0.81
HE4 (pg/mL)	0.8 (0.72–0.89)	2996.17	0.78	0.68	0.93	0.94	0.65
Leptin (pg/mL)	0.7 (0.58–0.82)	16,428.78	0.70	0.70	0.70	0.79	0.60
MIF (pg/mL)	0.55 (0.42–0.68)	95.17	0.58	0.55	0.63	0.70	0.48
PRL (pg/mL)	0.51 (0.38–0.64)	5065.74	0.51	0.21	0.97	0.91	0.44
Proteomic Model 2017	0.9 (0.82–0.97)	0.69	0.86	0.81	0.93	0.95	0.76
Proteomic Model 2021	0.82 (0.72–0.91)	0.85	0.77	0.64	0.97	0.97	0.63
Combined Model 2021	0.86 (0.78–0.95)	0.69	0.86	0.83	0.90	0.93	0.77
Full Combined Model 2021	0.89 (0.81–0.97)	0.67	0.87	0.83	0.93	0.95	0.78
ROMA-50	0.54 (0.38–0.69)	24.45	0.71	0.74	0.67	0.78	0.62
CPH-I	0.92 (0.85–0.98)	−0.72	0.86	0.83	0.90	0.93	0.77