Table 6.
Impact of clinical and pathological variables on survival, follow-up and respiratory complications. ASA: American Society of Anesthesiologists classification of physical status. COPD: Chronic Obstructive Pulmonary Disease. Mean ± 95% CI: 95% Confidence Interval.
| Features | Postoperative Death | Postoperative Complications | Respiratory Complications | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Yes | No | p-Value | No | Minor | Major | p-Value | Yes | No | p-Value | |
| Age, years | 72.91 ± 4.98 | 66.59 ± 9.81 | 0.031 | 65.93 ±9.94 | 67.85 ± 9.89 | 69.00 ± 8.17 | <0.001 | 69.36 ± 8.29 | 66.49 ± 9.86 | 0.0079 |
| Gender: n (%) | ||||||||||
| Men | 10 (0.93) | 606 (56.27) | 0.049 | 367 (34.08) | 61 (5.66) | 33 (3.06) | <0.001 | 51 (4.73) | 565 (52.46) | <0.001 |
| Women | 1 (0.09) | 460 (42.71) | 384 (35.65) | 131 (12.16) | 101 (9.39) | 13 (1.21) | 448 (41.60) | |||
| BMI (kg/m2) | 28.14 ± 4.88 | 25.24 ± 5.03 | 0.055 | 25.36 ± 5.05 | 25.20 ± 4.93 | 24.91 ± 5.04 | 0.64 | 25.72 ±5.68 | 25.24 ± 4.99 | 0.51 |
| Smoking status: n (%) | 0.94 | 0.011 | 0.0063 | |||||||
| Current | 3 (0.28) | 328 (30.65) | 225 (21.03) | 61 (5.70) | 45 (4.21) | 24 (2.24) | 307 (28.69) | |||
| Former | 6 (0.56) | 567 (52.99) | 386 (36.07) | 107 (10.00) | 80 (7.48) | 39 (3.64) | 534 (49.91) | |||
| Never | 2 (0.19) | 164 (15.33) | 134 (12.52) | 23 (2.15) | 9 (0.84) | 1 (0.09) | 165 (15.43) | |||
| FEV1 (% of predicted) | 68.27 ± 24.51 | 88.09 ± 20.52 | 0.0017 | 90.86 ± 19.73 | 81.70 ±21.16 | 80.33 ±21.08 | <0.001 | 77.00 ± 19.23 | 88.58 ± 20.56 | <0.001 |
| FVC (% of predicted) | 75.75 ± 11.67 | 97.39 ± 19.53 | 0.0020 | 99.71 ± 18.51 | 91.61 ± 20.94 | 90.21 ± 20.35 | <0.001 | 87.93 ±19.94 | 97.69 ± 19.44 | 0.0026 |
| DLCO (% of predicted) | 61.22 ± 16.07 | 68.22 ± 18.05 | 0.16 | 69.96 ± 17.51 | 66.22 ± 17.78 | 61.41 ± 19.22 | <0.001 | 61.41 ± 21.59 | 68.58 ± 17.69 | 0.031 |
| Ischemic Heart Disease: n (%) | 0.49 | 0.011 | 0.19 | |||||||
| Yes | 1 (0.09) | 239 (22.21) | 153 (14.22) | 44 (4.09) | 43 (4.00) | 10 (0.93) | 230 (21.38) | |||
| no | 10 (0.93) | 826 (76.77) | 597 (55.48) | 148 (13.75) | 91 (8.46) | 54 (5.02) | 782 (72.67) | |||
| Chronic obstructive pulmonary disease: n (%) | ||||||||||
| Yes | 7 (0.66) | 412 (38.25) | 0.17 | 255 (23.68) | 87 (8.08) | 77 (7.15) | <0.001 | 38 (3.53) | 381 (35.38) | <0.001 |
| no | 4 (0.37) | 654 (60.72) | 496 (46.05) | 105 (9.75) | 57 (5.29) | 26 (2.41) | 632 (58.68) | |||
| Score ASA: n (%) | ||||||||||
| I | 1 (0.09) | 409 (37.98) | 0.048 | 309 (28.69) | 57 (5.29) | 44 (4.09) | <0.001 | 11 (1.02) | 399 (37.05) | <0.001 |
| II | 5 (0.46) | 445 (41.33) | 323 (29.99) | 82 (7.61) | 45 (4.18) | 22 (2.04) | 428 (39.74) | |||
| III | 5 (0.46) | 212 (19.68) | 119 (11.05) | 53 (4.92) | 45 (4.18) | 31 (2.88) | 186 (17.27) | |||
| Thoracoscore | 4.59 ± 3.26 | 2.20 ± 1.84 | 0.0024 | 1.96 ± 1.42 | 2.71 ± 2.55 | 3.06 ± 2.49 | <0.001 | 3.44 ± 2.87 | 2.16 ± 1.78 | <0.001 |
| Pneumonectomy: n (%) | ||||||||||
| Yes | 2 (0.19) | 64 (5.94) | 0.30 | 31 (2.88) | 24 (2.23) | 11 (1.02) | <0.001 | 3 (0.28) | 63 (5.85) | 0.82 |
| No | 9 (0.83) | 1002 (93.04) | 720 (66.85) | 168 (15.60) | 123 (11.42) | 61 (5.66) | 950 (88.21) | |||
| Histology: (n = 1069): n (%) | 0.094 | <0.001 | <0.001 | |||||||
| Neuroendocrine | 3 (0.28) | 87 (8.14) | 69 (6.45) | 10 (0.94) | 11 (1.03) | 4 (0.37) | 86 (8.05) | |||
| Adenocarcinoma | 5 (0.47) | 709 (66.32) | 521 (48.74) | 119 (11.13) | 74 (6.92) | 31 (2.90) | 683 (63.89) | |||
| Epidermoid | 3 (0.28) | 207 (19.37) | 119 (11.13) | 50 (4.68) | 41 (3.83) | 26 (2.43) | 184 (17.22) | |||
| Others | - | 55 (5.16) | 37 (3.46) | 10 (0.94) | 8 (0.75) | 3 (0.28) | 52 (4.86) | |||
| pT: n (%) | 0.94 | 0.58 | 0.17 | |||||||
| 1 (a, b, c) | 5 (0.46) | 491 (45.59) | 355 (32.96) | 87 (8.08) | 54 (5.01) | 27 (2.50) | 469 (43.55) | |||
| 2 (a, b) | 4 (0.37) | 326 (30.27) | 231 (21.45) | 57 (5.29) | 42 (3.90) | 15 (1.39) | 315 (29.25) | |||
| 3 | 1 (0.09) | 162 (15.04) | 109 (10.12) | 32 (2.97) | 22 (2.04) | 14 (1.30) | 149 (13.84) | |||
| 4 | 1 (0.09) | 87 (8.09) | 56 (5.20) | 16 (1.49) | 16 (1.49) | 8 (0.74) | 80 (7.43) | |||