Table 1.

Physiological Predictors of Time to Local Failure: Thermal Dose Escalation Trial.

Variable	Parameter Estimate	Hazard Ratio	Score p-Value	Wald p-Value
HF Post-Pre	−0.0643	0.94	0.0070	0.0340
Median pO2 Post-Pre	0.0896	1.09	0.0230	0.0710
Pimo % area	−6.549	0.00	0.038	0.0510
PDE/ATP	0.2246	1.25	0.0490	0.0640

HF = Hypoxic Fraction—fraction of measurements <10 mmHg; N = 11 for HF and Median pO2; N = 16 Pimo area; N = 13 PDE/ATP; Pimo = pimonidazole; (PDE/ATP data previously published, Lora-Michaels et al. [109]).