Table 2.

CEM43Tx vs. change in volume, ADC, pO2, HF, iAUC: Thermal Dose Fractionation Trial.

Variable	N	CEM43T10		CEM43T50		CEM43T90
		Coefficient	p-Value	Coefficient	p-Value	Coefficient	p-Value
Change ADC Pre-post *	29	−0.53	0.0030	−0.56	0.0015	0.11	0.5665
iAUC change 24 h ^	17	0.07	0.7798	0.23	0.3599	0.5109	0.0311
Median pO2 change at 24 h ^	38	0.38	0.0214	0.27	0.1087	−0.07	0.9829
Change HF 24 h ^	38	−0.34	0.0451	−0.27	0.1074	−0.07	0.674
Volume change Pre-Post *	38	−0.42	0.0084	−0.36	0.0258	0.2983	0.17

* Total CEM43Tx; ^ CEM43Tx first HT; HF = % measurements < 10mmHg; iAUC = DCE-MRI perfusion parameter; HF = hypoxic fraction.