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. 2022 Mar 31;14(7):1769. doi: 10.3390/cancers14071769

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Proapoptotic effect of AEA and its metabolites formed via COX-2 and PGD synthase on tumorigenic keratinocytes. The arrows indicate the sequential activations and inductions triggered by the indicated substances. In the case where URB597 is listed with an inhibitory arrow directed at FAAH, URB597 resulted in an enhancement of the AEA effect shown. The dashed arrows indicate possible additional effects of AEA after degradation to arachidonic acid. All abbreviations are given in the text.