Table 2.
Relatives potentially eligible for genetic testing versus proportion of relatives that respondents intend to invite by degree of relationship and syndrome.
| Degree of Relationship | HBOC | LS | HBOC vs. LS a | |||
|---|---|---|---|---|---|---|
| Eligible (n) | Intend to Invite (n, %) | Eligible (n) | Intend to Invite (n, %) | p (Intend to Invite) | ||
| First-degree | Daughters | 173 | 76 (43.9%) | 42 | 18 (42.9%) | 1 |
| Sons | 175 | 86 (49.1%) | 38 | 15 (39.5%) | 0.37 | |
| Sisters | 235 | 78 (33.2%) | 40 | 14 (35.0%) | 0.97 | |
| Brothers | 215 | 84 (39.1%) | 49 | 18 (36.7%) | 0.89 | |
| Parents | 306 | 85 (27.8%) | 71 | 20 (28.2%) | 1 | |
| Sum | 1104 | 409 (37.0%) | 240 | 85 (35.4%) | 0.69 | |
| Second-degree | Granddaughters | 39 | 13 (33.3%) | 5 | 0 | 0.07 c |
| Grandsons | 33 | 8 (24.2%) | 10 | 2 (20.0%) | 1 b | |
| Nieces | 174 | 43 (24.7%) | 39 | 2 (5.1%) | 0.02 b | |
| Nephews | 214 | 47 (22.0%) | 39 | 7 (17.9%) | 0.83 b | |
| Half-sisters | 23 | 3 (13.0) | 7 | 2 (28.6%) | 0.59 b | |
| Half-brothers | 16 | 3 (18.8%) | 10 | 2 (20.0%) | 1 b | |
| Aunts | 322 | 47 (14.6%) | 60 | 6 (10.0%) | 0.54 b | |
| Uncles | 283 | 41 (14.5%) | 61 | 10 (16.4%) | 0.70 b | |
| Sum | 1104 | 205 (18.6%) | 231 | 31 (13.4%) | 0.08 | |
| Third-degree | Female cousins | 607 | 98 (16.1%) | 101 | 13 (12.9%) | 0.49 |
| Male cousins | 641 | 80 (12.5) | 129 | 18 (14.0%) | 0.75 | |
| Sum | 1248 | 178 (14.3%) | 230 | 31 (13.4%) | 0.83 | |
| Total | 3456 | 792 (22.9%) | 701 | 147 (21%) | 0.88 | |
| Between Degree of Relationship P (Sum) d |
<0.01 | <0.01 | ||||
| Between Gender P (Sum) d |
0.36 | 0.90 | ||||
a Two proportion z-test; b Fisher’s exact test; c binomial test; d Chi-square test; Bold = significant two-tailed p value ≤0.05.