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Location of claudin-2 and claudin-7 in normal mouse colon. (a) Normal claudin-2 distribution in cell membranes at the crypt base in the mouse colon (C57BL6/J mice, 6–8 weeks) (left panel: indicated by yellow arrows). (b) Normal claudin-7 distribution in cell membrane along crypt–villus axis in the mouse colon (right panel: indicated by yellow arrows) [28].
