Figure 1.

Model structures for unselected and FH/clinical-criteria-based genetic testing for BC patients and relatives: (a) for BC patients; (b) for relatives of BC patients. Abbreviations: BC, breast cancer; CPM, contralateral prophylactic mastectomy; FH, family history; OC, ovarian cancer; RRM, risk-reducing mastectomy; RRSO, risk-reducing salpingo-oophorectomy; path-var, pathogenic variant. * Includes individuals testing negative for BRCA1/BRCA2/PALB2 mutations and VUS not reclassified as pathologic variants. ** In the model structure for relatives, PALB2-positive individuals are identified only through the unselected testing arm. Relatives in the clinical criteria/FH testing arm only undergo BRCA1/BRCA2 testing. *** Unaffected relatives can progress from no cancer to germline BC (BRCA1/BRCA2/PALB2), germline OC (BRCA1/BRCA2), sporadic BC, or sporadic OC (or remain in that health state).