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. 2022 Apr 2;14(7):1814. doi: 10.3390/cancers14071814

Figure 1.

Figure 1

Different tumors induce body weight loss and muscle wasting in mice with different timing and tumor growth rate. In orange, 9–10 week-old male C26-bearing BALB/c mice start losing body weight already after 10 days from tumor injections and have lost 20% of body weight 12 days later, n = 9–10 (A). In blue, 9–10 week-old male MCG101-carrying C57BL6/J mice lose about 10% of their initial body weight after 20 days from tumor inoculation, n = 10–11 (B). In green, 9–10 week-old male LLC-bearing C57BL6/J mice present about 8% body wasting after 20 days, but this was not significant, n = 10 (C). Two-way ANOVA, * p ≤ 0.05, *** p ≤ 0.001, **** p ≤ 0.0001. In black, PBS-injected mice are indicated as controls (A–C). Tumor weights measured manually with a caliper over time are plotted (D). Ordinary one-way ANOVA, Tukey’s multiple comparisons test, not significant, n = 10–11. The weights of gastrocnemius (E) and tibialis anterior muscles (F) are reduced in all the tumor-bearing mice, but to different extents. In orange, C26 n = 18–20, in blue, MCG101 n = 20–22 and in green, LLC n = 20. Unpaired t-test, * p ≤ 0.05, ** p ≤ 0.01, **** p ≤ 0.0001.