Table 4.
Molecular markers—malignant bone tumors.
| Tumor Type | Genes/Molecular Profiles Characteristically Altered | Diagnostic Marker |
|---|---|---|
| Osteosarcoma |
TP53 RB1 8q21-24 (amplification) MDM2 (amplification) extensive and comprehensive chromosomal rearrangements |
+ |
| Ewing sarcoma | t(11;22)(q24;q12) EWSR1-FLI1 t(21;22)(q12;q12) EWSR1-ERG t(2;22)(q33;q12) EWSR1-CREB1 t(7;22)(p22;q12) EWSR1-ETV1 t(17;22)(q12;q12) EWSR1-E1AF inv(22)(q12;q12) EWSR1-ZSG t(16;21)(p11;q22) FUS-ERG and others |
+ |
| Chondrosarcoma |
HEY1-NCOA2 t(1;5)(q42;q32) RF2BP2-CDX1 IDH1 IDH2 TP53 |
+ |
| Giant cell tumor of soft tissue |
H3F3A
HRAS TP53 |
+ |