Table 1.
Functional classification of cancer-related proteins identified in ectosomes derived from 8305C human thyroid anaplastic carcinoma cells.
| Cell Proliferation (GO:0008283) |
Cell Migration (GO:0016477) |
Angiogenesis (GO:0001525) |
Immune Response (GO:0006955) |
Cellular Response to Drug (GO:0035690) |
|---|---|---|---|---|
| Cyclin-dependent kinase 1 (CDK1) Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1) H3 histone, family 3B (H3F3B ) Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) Minichromosome maintenance complex component 7 (MCM7) Myosin-10 (MYH10) Peroxiredoxin-1 (PRDX1) Protein scribble homolog (SCRIB) Proto-oncogene tyrosine protein kinase Src (SRC) Ras-related C3 botulinum toxin substrate 1 (RAC1) Ras-related protein Rap-1b (RAP1B) Thioredoxin reductase 1, cytoplasmic (TXNRD1) Transforming growth factor-beta-induced protein ig-h3 (TGFBI) Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) Ubiquitin-conjugating enzyme E2L 3 (UBE2L3) X-ray repair cross-complementing protein 5 (XRCC5) |
ADP-ribosylation factor 4 (ARF4) Asparagine-tRNA ligase, cytoplasmic (NARS1) CD151 antigen (CD151) CD44 antigen (CD44) CD63 antigen (CD63) Cell division control protein 42 homolog (CDC42) Collagen alpha-1(V) chain (CO5A1) Coronin-1B (CORO1B) Coronin-1C (CORO1C) Cullin-3 (CUL3) Cyclin-dependent kinase 1 (CKD1) Ephrin type-A receptor 2 (EPHA2) Fascin (FSCN1) Glypican-1 (GPC1) Guanine nucleotide exchange factor VAV2 (VAV2) Inactive tyrosine protein kinase 7 (PTK7) Integrin beta-1 (ITB1) Junction plakoglobin (PLAK) Laminin subunit alpha-5 (LAMA5) Laminin subunit beta-1 (LAMB1) Laminin subunit beta-2 (LAMB2) Laminin subunit gamma-1 (LAMC1) Microtubule-associated protein RP/EB family member 1 (MAPRE1) Nck-associated protein 1 (NCKP1) Neural cell adhesion molecule L1 (L1CAM) Protein scribble homolog (SCRIB) Ras GTPase-activating-like protein IQGAP1 (IQGAP1) Ras-related protein Rab-1A (RAB1A) Rho-related GTP-binding protein RhoA (RHOA) Thrombospondin-1 (TSP1) |
14-3-3 protein zeta/delta (YWHAZ) 72 kDa type IV collagenase (MMP2) Actin, cytoplasmic 2 (ACTG1) Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) Annexin A2 (ANXA2) ATP synthase subunit beta, mitochondrial (ATP5F1B) Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2) Caveolin-1 (CAV1) Chloride intracellular channel protein 4 (CLIC4) Collagen alpha-1(XVIII) chain (COL18A1) Collagen alpha-2(IV) chain (COL4A2) E3 ubiquitin-protein ligase RNF213 (RNF213) Fibronectin (FN1) Guanine nucleotide exchange factor VAV2 (VAV2) Integrin alpha-V (ITGAV) Lactadherin (MFGE8) Myosin-9 (MYH9) Nucleolin (NCL) Peptidyl-prolyl cis/trans isomerase H (PPIH) Plasminogen activator inhibitor 1 (PAI1) Programmed cell death protein 6 (PDCD6) Transforming growth factor-beta-induced protein ig-h3 (TGFBI) Tryptophan-tRNA ligase, cytoplasmic (WARS1) |
Complement C1r subcomponent (C1R) Complement C3 (C3) Deoxynucleoside triphosphate triphosphohydrolase (SAMHD1) HLA class I histocompatibility antigen, A alpha chain (HLA-A) HLA class I histocompatibility antigen, B-7 alpha chain (HLA-B) HLA class I histocompatibility antigen, Cw-7 alpha chain (HLA-C) Interferon-induced transmembrane protein 3 (IFITM3) Peroxidasin homolog (PXDN) Purine nucleoside phosphorylase (PNP) Thrombospondin-1 (THBS1) |
116 kDa U5 small nuclear ribonucleoprotein component (EFTUD2) 78 kDa glucose-regulated protein (HSPA5) CAD protein (CAD) Cellular tumor antigen p53 (TP53) Growth arrest-specific protein 6 (GAS6) Heat shock protein 90 alpha family class b member 1 (HSP90AB1) Nucleoside diphosphate kinase A (NME1) Ras-related protein Rap-1b (RAP1B) Transferrin receptor protein 1 (TFRC) Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) |