Table 2.
The distribution of genotype frequencies in KMT2C SNPs in cases-of-OSCC group.
| Variable | Controls (N = 284) | Patients (N = 284) | OR a (95% CI) | AOR b (95% CI) |
|---|---|---|---|---|
| rs201834857 | ||||
| CC | 134 (47.2%) | 131 (46.1%) | 1.000 | 1.000 |
| CT | 124 (43.7%) | 124 (43.1%) | 1.023 (0.723–1.446) | 0.699 (0.355–1.376) |
| TT | 26 (9.2%) | 29 (10.2%) | 1.141 (0.638–2.041) | 0.811 (0.281–2.336) |
| CT + TT | 150 (52.8) | 153 (53.9%) | 1.043 (0.750–1.451) | 0.722 (0.382–1.362) |
| rs4725443 | ||||
| TT | 209 (73.6%) | 180 (63.4%) | 1.000 | 1.000 |
| TC | 67 (23.6%) | 93 (32.7%) | 1.612 (1.111–2.338) * p = 0.012 |
1.298 (0.660–2.552) |
| CC | 8 (2.8%) | 11 (3.9%) | 1.597 (0.628–4.056) | 0.841 (0.106–6.667) |
| TC + CC | 75 (26.4%) | 104 (36.6%) | 1.610 (1.126–2.302) * p = 0.009 |
1.259 (0.651–2.435) |
| rs6464211 | ||||
| CC | 144 (50.7%) | 128 (45.1%) | 1.000 | 1.000 |
| CT | 112 (39.4%) | 124 (43.7%) | 1.246 (0.878–1.766) | 1.485 (0.765–2.885) |
| TT | 28 (9.9%) | 32 (11.3%) | 1.286 (0.734–2.252) | 0.911 (0.302–2.753) |
| CT + TT | 140 (49.3%) | 156 (54.9%) | 1.254 (0.901–1.743) | 1.358 (0.721–2.557) |
| rs6943984 | ||||
| GG | 209 (73.6%) | 215 (75.7) | 1.000 | 1.000 |
| GA | 64 (22.5%) | 66 (23.2%) | 1.002 (0.677–1.485) | 1.502 (0.729–3.095) |
| AA | 11 (3.9%) | 3 (1.1%) | 0.265 (0.073–0.964) * p = 0.044 |
0.046 (0.004–0.541) * p = 0.014 |
| GA + AA | 75 (26.4%) | 69 (24.3%) | 0.894 (0.613–1.306) | 1.215 (0.603–2.450) |
| rs74483926 | ||||
| GG | 189 (66.5%) | 200 (70.4%) | 1.000 | 1.000 |
| GA | 86 (30.3%) | 77 (27.1%) | 0.846 (0.587–1.220) | 0.794 (0.388–1.624) |
| AA | 9 (3.2%) | 7 (2.5%) | 0.735 (0.268–2.013) | 0.429 (0.036–5.139) |
| GA + AA | 95 (33.5%) | 84 (29.6%) | 0.836 (0.586–1.191) | 0.764 (0.379–1.539) |
N: number. * p-value < 0.05 is statistically significant. a The odds ratios (ORs) with their 95% confidence intervals were estimated by logistic regression models. b The adjusted odds ratios (AORs) with their 95% confidence intervals were estimated by multiple logistic regression models after controlling for betel nut chewing and alcohol and tobacco consumption.