Table 4.
Clinical statuses and KMT2C rs4725443 genotype frequencies in cases-of-OSCC group among 139 non-alcohol-drinking and 145 alcohol-drinking cases.
| Variable | KMT2C (rs4725443) | |||||
|---|---|---|---|---|---|---|
| Non-Alcohol-Drinking (N = 139) | Alcohol Drinking (N = 145) | |||||
| TT (%) (N = 88) |
TC + CC (%) (N = 51) |
p-Value | TT (%) (N = 92) |
TC + CC (%) (N = 53) |
p-Value | |
| Clinical stage | ||||||
| Stage I/II | 64 (72.7%) | 28 (54.9%) | p = 0.034 *,a | 47 (51.1%) | 29 (54.7%) | p = 0.673 |
| Stage III/IV | 24 (27.3%) | 23 (45.1%) | 45 (48.9%) | 24 (45.3%) | ||
| Tumor size | ||||||
| T1 + T2 | 70 (79.5%) | 33 (64.7%) | p = 0.057 | 56 (60.9%) | 34 (64.2%) | p = 0.695 |
| T3 + T4 | 18 (20.5%) | 18 (35.3%) | 36 (39.1%) | 19 (35.8%) | ||
| Lymph node metastasis | ||||||
| No | 74 (84.1%) | 39 (76.5%) | p = 0.269 | 65 (70.7%) | 38 (71.7%) | p = 0.894 |
| Yes | 14 (15.9%) | 12 (23.5%) | 27 (29.3%) | 15 (28.3%) | ||
| Distant metastasis | ||||||
| No | 84 (95.5%) | 48 (94.1%) | p = 0.729 | 85 (92.4%) | 49 (92.5%) | p = 0.989 |
| Yes | 4 (4.5%) | 3 (5.9%) | 7 (7.6%) | 4 (7.5%) | ||
| Cell differentiation | ||||||
| Good | 22 (25.0%) | 10 (19.6%) | p = 0.468 | 6 (6.5%) | 10 (18.9%) | p = 0.028 *,b |
| Moderate/poor | 66 (75.0%) | 41 (80.4%) | 86 (93.5%) | 43 (81.1%) | ||
N: number. Values were estimated by logistic regression models. * p-value < 0.05 is statistically significant. a OR (95% CI): 2.190 (1.062–4.519); b OR (95% CI): 0.300 (0.102–0.880).