The effects of Auricularia auricula-judae polysaccharides on HFFD induced mice body weight and fat accumulation. Seven-week-old male C57BL/6J mice were randomized into 6 groups (n = 10 per group): ND, ND + AAP, HFFD, and HFFD + AAP (Auricularia auricula-judae polysaccharide, 50, 100, 200 mg/kg/day, in feed) for 12 weeks. (A) Above: Timeline of C57BL/6J mice with AAP and/or HFFD treatment; Below: Body weight; (B) Above: Representative mouse pictures after 12 weeks feeding; Below: Body weight gain; (C) Weight of subcutaneous fat and epididymal fat. The data are presented as the mean ± SEM, * p < 0.05, ** p < 0.01, vs. ND group, # p < 0.05, ## p < 0.01 vs. HFFD group.