Skip to main content
. 2022 Mar 28;11(7):1146. doi: 10.3390/cells11071146

Figure 1.

Figure 1

Expression and processing of pre-pro-kisspeptin. Kisspeptins (KPs) are encoded as a common precursor. The pre-pro-kisspeptin is a 145 amino acid peptide, with a 19-amino acid signal peptide and a main 54-amino acid region (52 amino acid in in rodents), kisspeptin-54/52 (KP-54/52). KP-54/52 is further processed into peptides of lower molecular weight: KP-14, KP13, and KP-10. All KPs contain the RF-amide (in primates) or RG-amide (in rodents) motif in the C-terminus that can bind and activate the KP receptor.