Figure 10.

Role of kisspeptin signaling in metabolism. Kisspeptins (KP) and KP receptor (KPR) are present in liver, pancreas, fat, and gonad tissues. KPR^KO male mice suffered from with feeding suppression and decreased body weight. They had increased adiposity but did not develop glucose intolerance. In contrast, KPR^KO female mice gained bodyweight, higher leptin levels, marked adiposity with impaired glucose intolerance. The findings in KPR^KO mice suggest that KP-signaling impacts energy expenditure, food intake and body weight gain in a sexually dimorphic manner.