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. 2022 Apr 6;14(7):1848. doi: 10.3390/cancers14071848

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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BARD1 supports PDAC growth and modulates drug responses. (A,B) Colony formation assays in BARD1 silenced (siBARD1#1), and MiaPaCa-2 and Panc-1 cells treated with either olaparib or oxaliplatin at indicated concentrations; colonies were stained with Coomassie blue after 14 days. Graphs of Mean ± SEM from n = 3 are shown. * p < 0.05, ** p < 0.01, *** p < 0.001, n.s, non-significant. (Student’s t-test). (C,D) Pico Green cell survival curves in BARD1 silenced (siBARD1#1), and MiaPaCa-2 cells and Panc-1 cells were treated with either olaparib, oxaliplatin, or gemcitabine for 5 days. Representative graphs from n = 3 are shown. IC50 doses are shown in the table.