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. 2022 Mar 25;11(7):1108. doi: 10.3390/cells11071108

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The tumor promotion phenotype is mediated by secreted factors, expressed in either the heart or the tumor. (A) Serum levels of periostin, fibronectin and CTGF were determined via ELISA. (B,C) mRNA levels from either the heart (B) or tumor (C) of the indicated genes were measured by means of qRT-PCR, normalized with GAPDH (heart) or Hsp90 (tumor) house-keeping genes. Data are presented as relative expression compared with control, determined as 1. Data are presented as mean ± SEM and were analyzed via multiple Student’s t-tests. * p < 0.05. ** p < 0.01. *** p < 0.001.