Figure 5.

Cardiac remodeling in the absence of cardiac contractile dysfunction is sufficient for tumor promotion. The PE-infusion model. Cancer cells were implanted four weeks after the implantation of PE-infusing pumps. Cardiac remodeling occurred prior to tumor implantation with no apparent cardiac contractile dysfunction, although tumor progression was readily observed. Cardiac (orange and green dots) and tumor-secreted factors (yellow dots) are responsible for tumor growth in a paracrine and autocrine fashion.