TABLE 3.
Characteristics of E. coli ATCC 25922, EP1, EP2, EP2 acrA::Tn10-Km, EP1 ΔmarR, and EP2 complemented with wild-type marR
| E. coli straina | MIC (mg/liter)b
|
OST
|
mar sequence | Transcription of:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CIP | Tetracycline | Chloramphenicol | Cefazolin | Cefuroxime | H | H-CH, 3:1 | H-CH, 1:1 | CH | marA | acrA | ||
| ATCC 25922 | 0.006 | 3 | 3 | ND | ND | − | − | − | − | wt | + | + |
| EP1 | 16 | >256 (8)c | 4 | <2 | 4 | − | − | − | − | wt | ++ | + |
| EP2 | 256 | >256 (32)c | 32 | 4 | >16 | + | + | − | − | ΔA1821 | ++++ | ++ |
| EP2 acrA::Tn10-Km | 32 | ND | 0.75 | <2 | <2 | − | − | − | − | ΔA1821 | ++++ | ND |
| EP1 ΔmarR | 64–128 | ND | 32 | ND | ND | ND | ND | ND | ND | ΔA1821 | ++++ | ND |
| EP2 + wt marR | 64 | ND | 4 | ND | ND | ND | ND | ND | ND | wt | ++ | ND |
a
wt, wild type.
b
ND, not determined.
c
Two subpopulations.