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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Fatty acid metabolism modulates effector and memory CD8 T cells. FAO is essential for memory CD8+ cell generation through the AMPK/TRAF6 pathway. FAO in memory CD8+ cells is mainly fueled through FA uptake by CD36.