Table 1.

Morphological Adaptations of the NMJ to Aging.

Presynaptic	Authors
Increased complexity of nerve terminal branching	Khosa et al., 2019; Andonian and Fahim, 1989; Fahim, 1997
Increased nerve terminal branch number	Deschenes et al., 2020; Prakash and Sieck, 1998; Deschene et al., 2010
Increased total nerve terminal branch length	Robbins and Fahim, 1985; Deschenes et al., 2020; Deschenes et al., 2016
Increased planar area of nerve terminal branch length	Fahim, 1997; Prakash and Sieck, 1998
Increased area of vesicle clusters	Deschenes et al., 2011; Deschenes et al., 2010
Decreased total number of vesicles	Deschenes et al., 2015; Taetzch and Valdez, 2018
Decreased number and concentration of active zones	Nishimune et al., 2016
Postsynaptic	Authors
Abandoned incidence of abandoned endplate gutters	Rosenheimer and Smith, 1985; Bao et al., 2020
Increased fragmentation of receptors	Willadt et al., 2016; Deschenes et al., 2015; Hunter, 2016
Decreased length of endplate	Vaughn et al., 2019; Arnold et al., 2014
Decreased total area of endplate	Prakash and Sieck, 1998; Fahim and Robbins, 1982
Decreased perimeter length around endplate	Jang and Van Remmen, 2011; Elkerdany and Fahim, 1993
Increased expression of NCAM	Deschenes and Wilson, 2003