Table 2.

Physiological Adaptations of the NMJ to Aging.

Presynaptic Alterations	Authors
Increased quantal content	Fahim, 1997; Alshuaib and Fahim, 1990; Mahoney et al., 2014
Increased quantal size	Fahim, 1997; Jones et al., 2016
Increased spontaneous release of ACh	Smith, 1984; Smith and Weiler, 1987
Decreased calcium clearance from nerve terminal	Smith, 1987
Postsynaptic	Authors
Increased endplate potential amplitude	Iyer, 2021; Smith, 1987
Reduced safety factor of endplate potential	Giovannini et al., 2002; Liu et al., 2019
Increased synaptic depression during train of stimuli	Feng and Dai, 1990
Increased incidence of neurotransmission failure	Fahim, 1997; Smith and Weiler, 1987