Table 5.
KEGG pathway classifications of the differently expressed proteins (DEPs) in major dysmood disorder.
| Term ID All DEPs | Term Description | Observed | Background | Strength | FDR |
| hsa04060 | Cytokine–cytokine receptor interaction | 33 | 282 | 1.55 | 5.66 × 10−40 |
| hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 18 | 96 | 1.76 | 9.11 × 10−24 |
| hsa05200 | Pathways in cancer | 27 | 517 | 1.2 | 2.34 × 10−23 |
| hsa04657 | IL-17 signaling pathway | 17 | 92 | 1.75 | 1.56 × 10−22 |
| hsa05163 | Human cytomegalovirus infection | 20 | 218 | 1.45 | 2.33 × 10−21 |
| hsa04668 | TNF signaling pathway | 16 | 112 | 1.64 | 1.15 × 10−19 |
| hsa04630 | JAK-STAT signaling pathway | 17 | 160 | 1.51 | 4.88 × 10−19 |
| hsa04010 | MAPK signaling pathway | 19 | 288 | 1.3 | 7.36 × 10−18 |
| hsa05142 | Chagas disease | 13 | 99 | 1.6 | 1.72 × 10−15 |
| hsa04151 | PI3K-Akt signaling pathway | 18 | 350 | 1.2 | 4.03 × 10−15 |
| Term ID cluster2 | Term Description | Observed | Background | Strength | FDR |
| hsa04014 | Ras signaling pathway | 12 | 226 | 1.72 | 3.05 × 10−16 |
| hsa04010 | MAPK signaling pathway | 12 | 288 | 1.61 | 2.54 × 10−15 |
| hsa04015 | Rap1 signaling pathway | 11 | 202 | 1.73 | 3.35 × 10−15 |
| hsa04151 | PI3K-Akt signaling pathway | 12 | 350 | 1.53 | 1.23 × 10−14 |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 8 | 78 | 2 | 8.03 × 10−13 |
| hsa05205 | Proteoglycans in cancer | 9 | 196 | 1.65 | 1.08 × 10−11 |
| hsa05200 | Pathways in cancer | 11 | 517 | 1.32 | 3.19 × 10−11 |
| hsa05230 | Central carbon metabolism in cancer | 7 | 69 | 2 | 3.19 × 10−11 |
| hsa04510 | Focal adhesion | 7 | 198 | 1.54 | 3.20 × 10−28 |
| hsa04810 | Regulation of actin cytoskeleton | 7 | 209 | 1.52 | 4.15 × 10−8 |
| Term ID All DEPs | Disease Desription | Observed | Background | Strength | FDR |
| DOID:2914 | Immune system disease | 22 | 611 | 1.04 | 1.06 × 10−13 |
| DOID:612 | Primary immunodeficiency disease | 17 | 426 | 1.09 | 8.57 × 10−11 |
| DOID:0050589 | Inflammatory bowel disease | 9 | 52 | 1.72 | 5.12 × 10−10 |
| DOID:417 | Autoimmune disease | 14 | 294 | 1.16 | 1.05 × 10−9 |
| DOID:0060180 | Colitis | 7 | 22 | 1.99 | 3.60 × 10−9 |
| DOID:0060032 | Autoimmune disease of musculoskeletal system | 11 | 170 | 1.3 | 9.45 × 10−9 |
| DOID:0050117 | Disease by infectious agent | 13 | 317 | 1.1 | 2.25 × 10−8 |
| DOID:37 | Skin disease | 15 | 481 | 0.98 | 2.25 × 10−8 |
| DOID:77 | Gastrointestinal system disease | 15 | 510 | 0.95 | 4.38 × 10−8 |
| DOID:65 | Connective tissue disease | 17 | 715 | 0.86 | 4.60 × 10−8 |
KEGG: Kyoto Encyclopedia of Genes and Genomes; ID: Identification; FDR: false discovery rate; IL-17: interleukin; TNF: tumor necrosis factor; JAK-STAT: Janus-kinases–signal transducer and activator of transcription proteins; MAPK: mitogen-activated protein kinase; PI3K-Akt: Phosphatidylinositol 3-kinase–protein kinase B; EGFR: epidermal growth factor receptor.