Figure 1.

DCHP exposure does not affect metabolic phenotypes and plasma lipid profiles in LDLR^−/− mice. Four-week-old male PXR^F/FLDLR^−/− and PXR^ΔMyeLDLR^−/− littermates were treated with 10 mg/kg/day of DCHP or vehicle control daily by oral gavage for 12 weeks. Growth curve (A), major organ weight (B), glucose tolerance (C), and serum cholesterol and triglyceride levels (D) were measured. Data are represented as mean ± SEM (n = 6–12). subWAT, subcutaneous white adipose tissue; epiWAT, epididymal white adipose tissue; and BAT, brown adipose tissue.