Figure 2.

Exposure to DCHP leads to increased atherosclerosis in PXR^F/FLDLR^−/− but not PXR^ΔMyeLDLR^−/− mice. Four-week-old male PXR^F/FLDLR^−/− and PXR^ΔMyeLDLR^−/− littermates were treated with 10 mg/kg/day of DCHP or vehicle control daily by oral gavage for 12 weeks. Quantitative analysis of atherosclerotic lesion size in the aortic root and brachiocephalic artery (BCA) of PXR^F/FLDLR^−/− (A) and PXR^ΔMyeLDLR^−/− (B) mice (n = 9–10 per group, * p < 0.05). Representative Oil red O-stained sections are shown as indicated.